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Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation

PURPOSE: Polyphyllin VI, a main active saponin isolated from traditional medicinal plant Paris polyphylla, has exhibited antitumor activities in several cancer cell lines. In the present study, we investigated the antitumor effect of Polyphyllin VI against human osteosarcoma cells (U2OS) and the und...

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Publicado en:Drug Des Devel Ther
Main Authors: Yuan, Yong-Liang, Jiang, Neng, Li, Ze-Yun, Song, Zhi-Zhen, Yang, Zhi-Heng, Xue, Wen-Hua, Zhang, Xiao-Jian, Du, Yue
Formato: Artigo
Idioma:Inglês
Publicado: Dove 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717844/
https://ncbi.nlm.nih.gov/pubmed/31695327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S194961
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