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Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells

BACKGROUND: Celastrol, a triterpene compound derived from the traditional Chinese medicine Tripterygium wilfordii, has been reported to possess potential antitumor activity towards various malignancies. However, the effect of celastrol on glioma cells and the underlying molecular mechanisms remain e...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Liu, Xihong, Zhao, Peiyuan, Wang, Xiujuan, Wang, Lei, Zhu, Yingjun, Song, Yadi, Gao, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500040/
https://ncbi.nlm.nih.gov/pubmed/31053160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1173-4
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