Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to the Antimalarial Drug Fosmidomycin in E. coli

Sequence to activity mapping technologies are rapidly developing, enabling the generation and isolation of mutations conferring novel phenotypes. Here we used the CRISPR EnAbled Trackable genome Engineering (CREATE) technology to investigate the inhibition of the essential ispC gene in its native ge...

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Detaylı Bibliyografya
Yayımlandı:ACS Synth Biol
Asıl Yazarlar: Pines, Gur, Oh, Eun Joong, Bassalo, Marcelo C., Choudhury, Alaksh, Garst, Andrew D., Fankhauser, Reilly G., Eckert, Carrie A., Gill, Ryan T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928208/
https://ncbi.nlm.nih.gov/pubmed/30462485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.8b00219
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