Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to the Antimalarial Drug Fosmidomycin in E. coli

Sequence to activity mapping technologies are rapidly developing, enabling the generation and isolation of mutations conferring novel phenotypes. Here we used the CRISPR EnAbled Trackable genome Engineering (CREATE) technology to investigate the inhibition of the essential ispC gene in its native ge...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ACS Synth Biol
Egile Nagusiak: Pines, Gur, Oh, Eun Joong, Bassalo, Marcelo C., Choudhury, Alaksh, Garst, Andrew D., Fankhauser, Reilly G., Eckert, Carrie A., Gill, Ryan T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928208/
https://ncbi.nlm.nih.gov/pubmed/30462485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.8b00219
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