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Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene

Novel antimalarial drugs are urgently needed to treat severe malaria caused by Plasmodium falciparum. Isoprenoid biosynthesis is a promising target pathway, since the biosynthetic route in Plasmodia is biochemically distinct from the mevalonate pathway in humans. The small molecule fosmidomycin is a...

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Autori principali: Odom, Audrey R., Van Voorhis, Wesley C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814890/
https://ncbi.nlm.nih.gov/pubmed/20018214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2009.12.001
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