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Crystal Structure of Brucella abortus Deoxyxylulose-5-phosphate Reductoisomerase-like (DRL) Enzyme Involved in Isoprenoid Biosynthesis

Most bacteria use the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway for the synthesis of their essential isoprenoid precursors. The absence of the MEP pathway in humans makes it a promising new target for the development of much needed new and safe antimicrobial drugs. However, bacteria show a r...

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Bibliografiske detaljer
Main Authors: Pérez-Gil, Jordi, Calisto, Bárbara M., Behrendt, Christoph, Kurz, Thomas, Fita, Ignacio, Rodríguez-Concepción, Manuel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346137/
https://ncbi.nlm.nih.gov/pubmed/22442144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.354811
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