Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to the Antimalarial Drug Fosmidomycin in E. coli

Sequence to activity mapping technologies are rapidly developing, enabling the generation and isolation of mutations conferring novel phenotypes. Here we used the CRISPR EnAbled Trackable genome Engineering (CREATE) technology to investigate the inhibition of the essential ispC gene in its native ge...

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Bibliographic Details
Published in:ACS Synth Biol
Main Authors: Pines, Gur, Oh, Eun Joong, Bassalo, Marcelo C., Choudhury, Alaksh, Garst, Andrew D., Fankhauser, Reilly G., Eckert, Carrie A., Gill, Ryan T.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928208/
https://ncbi.nlm.nih.gov/pubmed/30462485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.8b00219
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