ADAM10 sheddase activation is controlled by cell membrane asymmetry

Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer’s disease. The mechanisms underlying ADAM10 sheddase activation are incompletely understood. Here, we show that transient exposure of the negatively charged p...

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Detalhes bibliográficos
Publicado no:J Mol Cell Biol
Main Authors: Bleibaum, Florian, Sommer, Anselm, Veit, Martin, Rabe, Björn, Andrä, Jörg, Kunzelmann, Karl, Nehls, Christian, Correa, Wilmar, Gutsmann, Thomas, Grötzinger, Joachim, Bhakdi, Sucharit, Reiss, Karina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927242/
https://ncbi.nlm.nih.gov/pubmed/30753537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjz008
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