ADAM10 sheddase activation is controlled by cell membrane asymmetry

Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer’s disease. The mechanisms underlying ADAM10 sheddase activation are incompletely understood. Here, we show that transient exposure of the negatively charged p...

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Bibliografische gegevens
Gepubliceerd in:J Mol Cell Biol
Hoofdauteurs: Bleibaum, Florian, Sommer, Anselm, Veit, Martin, Rabe, Björn, Andrä, Jörg, Kunzelmann, Karl, Nehls, Christian, Correa, Wilmar, Gutsmann, Thomas, Grötzinger, Joachim, Bhakdi, Sucharit, Reiss, Karina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927242/
https://ncbi.nlm.nih.gov/pubmed/30753537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjz008
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