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Mutagenesis of the ADAM17-phosphatidylserine–binding motif leads to embryonic lethality in mice
ADAM17, prominent member of the “Disintegrin and Metalloproteinase” (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Several of these play central roles in oncogenesis and inflammation, yet despite its importance, the mechanism by which ADAM17 is activat...
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| Published in: | Life Sci Alliance |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Life Science Alliance LLC
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6712283/ https://ncbi.nlm.nih.gov/pubmed/31455669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900430 |
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