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Mutagenesis of the ADAM17-phosphatidylserine–binding motif leads to embryonic lethality in mice
ADAM17, prominent member of the “Disintegrin and Metalloproteinase” (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Several of these play central roles in oncogenesis and inflammation, yet despite its importance, the mechanism by which ADAM17 is activat...
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| Publicado no: | Life Sci Alliance |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Life Science Alliance LLC
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6712283/ https://ncbi.nlm.nih.gov/pubmed/31455669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900430 |
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