Mutagenesis of the ADAM17-phosphatidylserine–binding motif leads to embryonic lethality in mice

ADAM17, prominent member of the “Disintegrin and Metalloproteinase” (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Several of these play central roles in oncogenesis and inflammation, yet despite its importance, the mechanism by which ADAM17 is activat...

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Bibliographic Details
Published in:Life Sci Alliance
Main Authors: Veit, Martin, Ahrens, Björn, Seidel, Jana, Sommer, Anselm, Bhakdi, Sucharit, Reiss, Karina
Format: Artigo
Language:Inglês
Published: Life Science Alliance LLC 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712283/
https://ncbi.nlm.nih.gov/pubmed/31455669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900430
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