Phosphatidylserine exposure is required for ADAM17 sheddase function

ADAM17, a prominent member of the ‘Disintegrin and Metalloproteinase' (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Here we present evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity. PS exp...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Sommer, Anselm, Kordowski, Felix, Büch, Joscha, Maretzky, Thorsten, Evers, Astrid, Andrä, Jörg, Düsterhöft, Stefan, Michalek, Matthias, Lorenzen, Inken, Somasundaram, Prasath, Tholey, Andreas, Sönnichsen, Frank D., Kunzelmann, Karl, Heinbockel, Lena, Nehls, Christian, Gutsmann, Thomas, Grötzinger, Joachim, Bhakdi, Sucharit, Reiss, Karina
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866515/
https://ncbi.nlm.nih.gov/pubmed/27161080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11523
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