Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding

ADAM17, a prominent member of the “Disintegrin and Metalloproteinase” (ADAM) family, is an important regulator of endothelial cell proliferation and cell survival. The protease controls vital cellular functions through cleavage of growth factors, cytokines and their receptors including transforming...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Sommer, Anselm, Düppe, Marie, Baumecker, Lena, Kordowski, Felix, Büch, Joscha, Chico, Johaiber Fuchslocher, Fritsch, Jürgen, Schütze, Stefan, Adam, Dieter, Sperrhacke, Maria, Bhakdi, Sucharit, Reiss, Karina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641154/
https://ncbi.nlm.nih.gov/pubmed/29069811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19983
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