Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding

ADAM17, a prominent member of the “Disintegrin and Metalloproteinase” (ADAM) family, is an important regulator of endothelial cell proliferation and cell survival. The protease controls vital cellular functions through cleavage of growth factors, cytokines and their receptors including transforming...

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Vydáno v:Oncotarget
Hlavní autoři: Sommer, Anselm, Düppe, Marie, Baumecker, Lena, Kordowski, Felix, Büch, Joscha, Chico, Johaiber Fuchslocher, Fritsch, Jürgen, Schütze, Stefan, Adam, Dieter, Sperrhacke, Maria, Bhakdi, Sucharit, Reiss, Karina
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641154/
https://ncbi.nlm.nih.gov/pubmed/29069811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19983
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