Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding

ADAM17, a prominent member of the “Disintegrin and Metalloproteinase” (ADAM) family, is an important regulator of endothelial cell proliferation and cell survival. The protease controls vital cellular functions through cleavage of growth factors, cytokines and their receptors including transforming...

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Publicado en:Oncotarget
Autores principales: Sommer, Anselm, Düppe, Marie, Baumecker, Lena, Kordowski, Felix, Büch, Joscha, Chico, Johaiber Fuchslocher, Fritsch, Jürgen, Schütze, Stefan, Adam, Dieter, Sperrhacke, Maria, Bhakdi, Sucharit, Reiss, Karina
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641154/
https://ncbi.nlm.nih.gov/pubmed/29069811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19983
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