Intramolecular interaction in LGN, an adaptor protein that regulates mitotic spindle orientation

Proper mitotic spindle orientation requires that astral microtubules are connected to the cell cortex by the microtubule-binding protein NuMA, which is recruited from the cytoplasm. Cortical recruitment of NuMA is at least partially mediated via direct binding to the adaptor protein LGN. LGN normall...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Takayanagi, Hiroki, Hayase, Junya, Kamakura, Sachiko, Miyano, Kei, Chishiki, Kanako, Yuzawa, Satoru, Sumimoto, Hideki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926459/
https://ncbi.nlm.nih.gov/pubmed/31732560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011457
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