Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

Understanding HIV-1 persistence despite antiretroviral therapy (ART) is of paramount importance. Both single-genome sequencing (SGS) and integration site analysis (ISA) provide useful information regarding the structure of persistent HIV DNA populations; however, until recently, there was no way to...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Patro, Sean C., Brandt, Leah D., Bale, Michael J., Halvas, Elias K., Joseph, Kevin W., Shao, Wei, Wu, Xiaolin, Guo, Shuang, Murrell, Ben, Wiegand, Ann, Spindler, Jonathan, Raley, Castle, Hautman, Christopher, Sobolewski, Michele, Fennessey, Christine M., Hu, Wei-Shau, Luke, Brian, Hasson, Jenna M., Niyongabo, Aurelie, Capoferri, Adam A., Keele, Brandon F., Milush, Jeff, Hoh, Rebecca, Deeks, Steven G., Maldarelli, Frank, Hughes, Stephen H., Coffin, John M., Rausch, Jason W., Mellors, John W., Kearney, Mary F.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925994/
https://ncbi.nlm.nih.gov/pubmed/31776247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910334116
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