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Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

Understanding HIV-1 persistence despite antiretroviral therapy (ART) is of paramount importance. Both single-genome sequencing (SGS) and integration site analysis (ISA) provide useful information regarding the structure of persistent HIV DNA populations; however, until recently, there was no way to...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Patro, Sean C., Brandt, Leah D., Bale, Michael J., Halvas, Elias K., Joseph, Kevin W., Shao, Wei, Wu, Xiaolin, Guo, Shuang, Murrell, Ben, Wiegand, Ann, Spindler, Jonathan, Raley, Castle, Hautman, Christopher, Sobolewski, Michele, Fennessey, Christine M., Hu, Wei-Shau, Luke, Brian, Hasson, Jenna M., Niyongabo, Aurelie, Capoferri, Adam A., Keele, Brandon F., Milush, Jeff, Hoh, Rebecca, Deeks, Steven G., Maldarelli, Frank, Hughes, Stephen H., Coffin, John M., Rausch, Jason W., Mellors, John W., Kearney, Mary F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925994/
https://ncbi.nlm.nih.gov/pubmed/31776247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910334116
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