Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV

Human immunodeficiency virus (HIV) can adapt to an individual’s T cell immune response via genomic mutations that affect antigen recognition and impact disease outcome. These viral adaptations are specific to the host’s human leucocyte antigen (HLA) alleles, as these molecules determine which peptid...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Currenti, Jennifer, Chopra, Abha, John, Mina, Leary, Shay, McKinnon, Elizabeth, Alves, Eric, Pilkinton, Mark, Smith, Rita, Barnett, Louise, McDonnell, Wyatt J., Lucas, Michaela, Noel, Francine, Mallal, Simon, Conrad, Joseph A., Kalams, Spyros A., Gaudieri, Silvana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924686/
https://ncbi.nlm.nih.gov/pubmed/31821379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008177
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