Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses

Since HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1 sequences to stimulate and detect T-cell resp...

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Detalhes bibliográficos
Main Authors: Almeida, Coral-Ann M, Roberts, Steven G, Laird, Rebecca, McKinnon, Elizabeth, Ahmad, Imran, Keane, Niamh M, Chopra, Abha, Kadie, Carl, Heckerman, David, Mallal, Simon, John, Mina
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949439/
https://ncbi.nlm.nih.gov/pubmed/20619380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.06.091
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