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Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses
Since HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1 sequences to stimulate and detect T-cell resp...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949439/ https://ncbi.nlm.nih.gov/pubmed/20619380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.06.091 |
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