High-avidity, high-IFNγ-producing CD8 T-cell responses following immune selection during HIV-1 infection

HIV-1 mutations which reduce or abolish cytotoxic T lymphocyte responses against virus-infected cells are frequently selected in acute and chronic HIV-infection. Among population HIV-1 sequences, immune selection is evident as HLA allele-associated substitutions of amino acids within or near CD8 T c...

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Main Authors: Keane, Niamh M., Roberts, Steven G., Almeida, Coral-Ann M., Krishnan, Tanya, Chopra, Abha, Demaine, Emma, Laird, Rebecca, Tschochner, Monika, Carlson, Jonathan M., Mallal, Simon, Heckerman, David, James, Ian, John, Mina
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173576/
https://ncbi.nlm.nih.gov/pubmed/21577229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2011.34
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