Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV

Human immunodeficiency virus (HIV) can adapt to an individual’s T cell immune response via genomic mutations that affect antigen recognition and impact disease outcome. These viral adaptations are specific to the host’s human leucocyte antigen (HLA) alleles, as these molecules determine which peptid...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Currenti, Jennifer, Chopra, Abha, John, Mina, Leary, Shay, McKinnon, Elizabeth, Alves, Eric, Pilkinton, Mark, Smith, Rita, Barnett, Louise, McDonnell, Wyatt J., Lucas, Michaela, Noel, Francine, Mallal, Simon, Conrad, Joseph A., Kalams, Spyros A., Gaudieri, Silvana
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924686/
https://ncbi.nlm.nih.gov/pubmed/31821379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008177
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