Chondroitinase ABC reduces dopaminergic nigral cell death and striatal terminal loss in a 6-hydroxydopamine partial lesion mouse model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is characterised by dopaminergic cell loss within the substantia nigra pars compacta (SNc) that leads to reduced striatal dopamine content and resulting motor deficits. Identifying new strategies to protect these cells from degeneration and retain striatal dopami...

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Udgivet i:BMC Neurosci
Main Authors: Fletcher, Edward J. R., Moon, Lawrence D. F., Duty, Susan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923832/
https://ncbi.nlm.nih.gov/pubmed/31862005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-019-0543-3
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