Epothilone B Benefits Nigral Dopaminergic Neurons by Attenuating Microglia Activation in the 6-Hydroxydopamine Lesion Mouse Model of Parkinson’s Disease

Parkinson’s disease (PD) is characterized by loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc) and a subsequent reduction in striatal DA levels. Recent studies have shown that systemic administration of subtoxic doses of epothilone B (EpoB), a microtubule stabilizing agent, e...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Yu, Zhongyuan, Yang, Ling, Yang, Yang, Chen, Siyu, Sun, Dayu, Xu, Haiwei, Fan, Xiaotang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172330/
https://ncbi.nlm.nih.gov/pubmed/30323743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00324
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