Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease

The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s disease. Brain inflammation, microglia and astroglia...

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Udgivet i:Front Cell Neurosci
Main Authors: García-Domínguez, Irene, Veselá, Karolina, García-Revilla, Juan, Carrillo-Jiménez, Alejandro, Roca-Ceballos, María Angustias, Santiago, Marti, de Pablos, Rocío M., Venero, José L.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232526/
https://ncbi.nlm.nih.gov/pubmed/30459561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00398
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