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Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease

The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s disease. Brain inflammation, microglia and astroglia...

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發表在:Front Cell Neurosci
Main Authors: García-Domínguez, Irene, Veselá, Karolina, García-Revilla, Juan, Carrillo-Jiménez, Alejandro, Roca-Ceballos, María Angustias, Santiago, Marti, de Pablos, Rocío M., Venero, José L.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232526/
https://ncbi.nlm.nih.gov/pubmed/30459561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00398
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