Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease

The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s disease. Brain inflammation, microglia and astroglia...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: García-Domínguez, Irene, Veselá, Karolina, García-Revilla, Juan, Carrillo-Jiménez, Alejandro, Roca-Ceballos, María Angustias, Santiago, Marti, de Pablos, Rocío M., Venero, José L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232526/
https://ncbi.nlm.nih.gov/pubmed/30459561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00398
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