Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

The endoplasmic reticulum (ER) is responsible for folding secretory and membrane proteins, but disturbed ER proteostasis may lead to protein aggregation and subsequent cellular and clinical pathologies. Chemical chaperones have recently emerged as a potential therapeutic approach for ER stress-relat...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kitakaze, Keisuke, Taniuchi, Shusuke, Kawano, Eri, Hamada, Yoshimasa, Miyake, Masato, Oyadomari, Miho, Kojima, Hirotatsu, Kosako, Hidetaka, Kuribara, Tomoko, Yoshida, Suguru, Hosoya, Takamitsu, Oyadomari, Seiichi
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6922633/
https://ncbi.nlm.nih.gov/pubmed/31843052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43302
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados