Nanosecond pulsed electric fields induce the integrated stress response via reactive oxygen species-mediated heme-regulated inhibitor (HRI) activation

The integrated stress response (ISR) is one of the most important cytoprotective mechanisms and is integrated by phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α). Four eIF2α kinases, heme-regulated inhibitor (HRI), double-stranded RNA-dependent protein kinase (P...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hamada, Yoshimasa, Furumoto, Yuji, Izutani, Akira, Taniuchi, Shusuke, Miyake, Masato, Oyadomari, Miho, Teranishi, Kenji, Shimomura, Naoyuki, Oyadomari, Seiichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064201/
https://ncbi.nlm.nih.gov/pubmed/32155190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229948
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