Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion

Prion or PrP(Sc) is the proteinaceous infectious agent causing prion diseases in various mammalian species. Despite decades of research, the structural basis for PrP(Sc) formation and prion infectivity remains elusive. To understand the role of the hydrophobic region in forming infectious prion at t...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Abskharon, Romany, Wang, Fei, Wohlkonig, Alexandre, Ruan, Juxin, Soror, Sameh, Giachin, Gabriele, Pardon, Els, Zou, Wenquan, Legname, Giuseppe, Ma, Jiyan, Steyaert, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6922452/
https://ncbi.nlm.nih.gov/pubmed/31815959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008139
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