Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion

Prion or PrP(Sc) is the proteinaceous infectious agent causing prion diseases in various mammalian species. Despite decades of research, the structural basis for PrP(Sc) formation and prion infectivity remains elusive. To understand the role of the hydrophobic region in forming infectious prion at t...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Abskharon, Romany, Wang, Fei, Wohlkonig, Alexandre, Ruan, Juxin, Soror, Sameh, Giachin, Gabriele, Pardon, Els, Zou, Wenquan, Legname, Giuseppe, Ma, Jiyan, Steyaert, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6922452/
https://ncbi.nlm.nih.gov/pubmed/31815959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008139
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