Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein

Prion disorders are infectious diseases that are characterized by the conversion of the cellular prion protein PrP(C) into the pathogenic isoform PrP(Sc). Specific antibodies that interact with the cellular prion protein have been shown to inhibit this transition. Recombinant VHHs (variable domain o...

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Détails bibliographiques
Auteurs principaux: Abskharon, Romany N. N., Soror, Sameh H., Pardon, Els, El Hassan, Hassan, Legname, Giuseppe, Steyaert, Jan, Wohlkonig, Alexandre
Format: Artigo
Langue:Inglês
Publié: International Union of Crystallography 2010
Sujets:
Crystallization Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998374/
https://ncbi.nlm.nih.gov/pubmed/21139215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110042168
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