Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein

Prion disorders are infectious diseases that are characterized by the conversion of the cellular prion protein PrP(C) into the pathogenic isoform PrP(Sc). Specific antibodies that interact with the cellular prion protein have been shown to inhibit this transition. Recombinant VHHs (variable domain o...

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Detalhes bibliográficos
Main Authors: Abskharon, Romany N. N., Soror, Sameh H., Pardon, Els, El Hassan, Hassan, Legname, Giuseppe, Steyaert, Jan, Wohlkonig, Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2010
Assuntos:
Crystallization Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998374/
https://ncbi.nlm.nih.gov/pubmed/21139215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110042168
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