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Prion infectivity is encoded exclusively within the structure of proteinase K-resistant fragments of synthetically generated recombinant PrP(Sc)

Transmissible spongiform encephalopathies, also known as prion diseases, are a group of fatal neurodegenerative disorders affecting both humans and animals. The central pathogenic event in prion disease is the misfolding of normal prion protein (PrP(C)) into the pathogenic conformer, PrP(Sc), which...

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Foilsithe in:Acta Neuropathol Commun
Main Authors: Wang, Fei, Wang, Xinhe, Abskharon, Romany, Ma, Jiyan
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921397/
https://ncbi.nlm.nih.gov/pubmed/29699569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0534-0
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