Filling Adeno-Associated Virus Capsids: Estimating Success by Cryo-Electron Microscopy

Adeno-associated viruses (AAVs) have been employed successfully as gene therapy vectors in treating various genetic diseases for almost two decades. However, transgene packaging is usually imperfect, and developing a rapid and accurate method for measuring the proportion of DNA encapsidation is an i...

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Bibliografiske detaljer
Udgivet i:Hum Gene Ther
Main Authors: Subramanian, Suriyasri, Maurer, Anna C., Bator, Carol M., Makhov, Alexander M., Conway, James F., Turner, Kevin B., Marden, James H., Vandenberghe, Luk H., Hafenstein, Susan L.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc., publishers 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921155/
https://ncbi.nlm.nih.gov/pubmed/31530236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2019.041
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