Cryo-EM maps reveal five-fold channel structures and their modification by gatekeeper mutations in the parvovirus minute virus of mice (MVM) capsid

In minute virus of mice (MVM) capsids, icosahedral five-fold channels serve as portals mediating genome packaging, genome release, and the phased extrusion of viral peptides. Previous studies suggest that residues L172 and V40 are essential for channel function. The structures of MVMi wildtype, and...

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Veröffentlicht in:Virology
Hauptverfasser: Subramanian, Suriyasri, Organtini, Lindsey J., Grossman, Alec, Domeier, Phillip P., Cifuente, Javier O., Makhov, Alexander M., Conway, James F., D’Abramo, Anthony, Cotmore, Susan F., Tattersall, Peter, Hafenstein, Susan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601314/
https://ncbi.nlm.nih.gov/pubmed/28750325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.07.015
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