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Depletion of Virion-Associated Divalent Cations Induces Parvovirus Minute Virus of Mice To Eject Its Genome in a 3′-to-5′ Direction from an Otherwise Intact Viral Particle

We describe a structural rearrangement that can occur in parvovirus minute virus of mice (MVMp) virions following prolonged exposure to buffers containing 0.5 mM EDTA. Such particles remain stable at 4°C but undergo a conformational shift upon heating to 37°C at pH 7.2 that leads to the ejection of...

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書目詳細資料
Main Authors: Cotmore, Susan F., Hafenstein, Susan, Tattersall, Peter
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812381/
https://ncbi.nlm.nih.gov/pubmed/19955311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01563-09
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