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HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species
Inactivation of the VHL tumor suppressor gene is the signature initiating event in clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, and causes the accumulation of hypoxia-inducible factor 2α (HIF-2α). HIF-2α inhibitors are effective in some ccRCC cases, but both de nov...
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| Udgivet i: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6913182/ https://ncbi.nlm.nih.gov/pubmed/31575731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay0482 |
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