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Synthetic Lethality Screens Using RNAi in Combination with CRISPR-based Knockout in Drosophila Cells

A synthetic lethal interaction is a type of genetic interaction where the disruption of either of two genes individually has little effect but their combined disruption is lethal. Knowledge of synthetic lethal interactions can allow for elucidation of network structure and identification of candidat...

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Dettagli Bibliografici
Pubblicato in:Bio Protoc
Autori principali: Housden, Benjamin E., Nicholson, Hilary E., Perrimon, Norbert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Bio-Protocol 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432019/
https://ncbi.nlm.nih.gov/pubmed/28523286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.2119
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