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Synthetic Lethality Screens Using RNAi in Combination with CRISPR-based Knockout in Drosophila Cells

A synthetic lethal interaction is a type of genetic interaction where the disruption of either of two genes individually has little effect but their combined disruption is lethal. Knowledge of synthetic lethal interactions can allow for elucidation of network structure and identification of candidat...

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Библиографические подробности
Опубликовано в: :Bio Protoc
Главные авторы: Housden, Benjamin E., Nicholson, Hilary E., Perrimon, Norbert
Формат: Artigo
Язык:Inglês
Опубликовано: Bio-Protocol 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432019/
https://ncbi.nlm.nih.gov/pubmed/28523286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.2119
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