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Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA)
Synthetic sick or synthetic lethal (SS/L) screens are a powerful way to identify candidate drug targets to specifically kill tumor cells, but this approach generally suffers from low consistency between screens. We found that many SS/L interactions involve essential genes and are therefore detectabl...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5740648/ https://ncbi.nlm.nih.gov/pubmed/29183982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713362114 |
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