TBK1 is a Synthetic Lethal Target in Cancer with VHL Loss

TANK Binding Kinase 1 (TBK1) is an important kinase involved in innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from kidney cancer patients with VHL loss display elevated TBK1 phosphorylation. Loss of TBK1 via ge...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Discov
Prif Awduron: Hu, Lianxin, Xie, Haibiao, Liu, Xijuan, Potjewyd, Frances, James, Lindsey I., Wilkerson, Emily M., Herring, Laura E., Xie, Ling, Chen, Xian, Cabrera, Johnny Castillo, Hong, Kai, Liao, Chengheng, Tan, Xianming, Baldwin, Albert S., Gong, Kan, Zhang, Qing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058506/
https://ncbi.nlm.nih.gov/pubmed/31810986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0837
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg