Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss

von Hippel-Lindau (VHL) is a critical tumor suppressor in clear cell renal cell carcinomas (ccRCCs). It is important to identify additional therapeutic targets in ccRCC downstream of VHL loss besides hypoxia inducible factor 2α (HIF2α). By performing a genome-wide screen, we identified Scm-like with...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Liu, Xijuan, Simon, Jeremy M., Xie, Haibiao, Hu, Lianxin, Wang, Jun, Zurlo, Giada, Fan, Cheng, Ptacek, Travis S., Herring, Laura, Tan, Xianming, Li, Mingjie, Baldwin, Albert S., Kim, William Y., Wu, Tao, Kirschner, Marc W., Gong, Kan, Zhang, Qing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093231/
https://ncbi.nlm.nih.gov/pubmed/32023483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.01.009
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