Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

Protein hydroxylation affects protein stability, activity, and interactome, therefore contributing to various diseases including cancers. However, the transiency of the hydroxylation reaction hinders the identification of hydroxylase substrates. By developing an enzyme-substrate trapping strategy co...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zurlo, Giada, Liu, Xijuan, Takada, Mamoru, Fan, Cheng, Simon, Jeremy M., Ptacek, Travis S., Rodriguez, Javier, von Kriegsheim, Alex, Liu, Juan, Locasale, Jason W., Robinson, Adam, Zhang, Jing, Holler, Jessica M., Kim, Baek, Zikánová, Marie, Bierau, Jörgen, Xie, Ling, Chen, Xian, Li, Mingjie, Perou, Charles M., Zhang, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858455/
https://ncbi.nlm.nih.gov/pubmed/31729379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13168-4
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