Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

Protein hydroxylation affects protein stability, activity, and interactome, therefore contributing to various diseases including cancers. However, the transiency of the hydroxylation reaction hinders the identification of hydroxylase substrates. By developing an enzyme-substrate trapping strategy co...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Zurlo, Giada, Liu, Xijuan, Takada, Mamoru, Fan, Cheng, Simon, Jeremy M., Ptacek, Travis S., Rodriguez, Javier, von Kriegsheim, Alex, Liu, Juan, Locasale, Jason W., Robinson, Adam, Zhang, Jing, Holler, Jessica M., Kim, Baek, Zikánová, Marie, Bierau, Jörgen, Xie, Ling, Chen, Xian, Li, Mingjie, Perou, Charles M., Zhang, Qing
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858455/
https://ncbi.nlm.nih.gov/pubmed/31729379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13168-4
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