Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

Protein hydroxylation affects protein stability, activity, and interactome, therefore contributing to various diseases including cancers. However, the transiency of the hydroxylation reaction hinders the identification of hydroxylase substrates. By developing an enzyme-substrate trapping strategy co...

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Vydáno v:Nat Commun
Hlavní autoři: Zurlo, Giada, Liu, Xijuan, Takada, Mamoru, Fan, Cheng, Simon, Jeremy M., Ptacek, Travis S., Rodriguez, Javier, von Kriegsheim, Alex, Liu, Juan, Locasale, Jason W., Robinson, Adam, Zhang, Jing, Holler, Jessica M., Kim, Baek, Zikánová, Marie, Bierau, Jörgen, Xie, Ling, Chen, Xian, Li, Mingjie, Perou, Charles M., Zhang, Qing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858455/
https://ncbi.nlm.nih.gov/pubmed/31729379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13168-4
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