TBK1 is a Synthetic Lethal Target in Cancer with VHL Loss

TANK Binding Kinase 1 (TBK1) is an important kinase involved in innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from kidney cancer patients with VHL loss display elevated TBK1 phosphorylation. Loss of TBK1 via ge...

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Détails bibliographiques
Publié dans:Cancer Discov
Auteurs principaux: Hu, Lianxin, Xie, Haibiao, Liu, Xijuan, Potjewyd, Frances, James, Lindsey I., Wilkerson, Emily M., Herring, Laura E., Xie, Ling, Chen, Xian, Cabrera, Johnny Castillo, Hong, Kai, Liao, Chengheng, Tan, Xianming, Baldwin, Albert S., Gong, Kan, Zhang, Qing
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058506/
https://ncbi.nlm.nih.gov/pubmed/31810986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0837
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