Folic acid supplementation reduces multigenerational sperm miRNA perturbation induced by in utero environmental contaminant exposure

Persistent organic pollutants (POPs) can induce epigenetic changes in the paternal germline. Here, we report that folic acid (FA) supplementation mitigates sperm miRNA profiles transgenerationally following in utero paternal exposure to POPs in a rat model. Pregnant founder dams were exposed to an e...

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Vydáno v:Environ Epigenet
Hlavní autoři: Herst, P M, Dalvai, M, Lessard, M, Charest, P L, Navarro, P, Joly-Beauparlant, C, Droit, A, Trasler, J M, Kimmins, S, MacFarlane, A J, Benoit-Biancamano, M-O, Bailey, J L
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911352/
https://ncbi.nlm.nih.gov/pubmed/31853372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eep/dvz024
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