Folic acid supplementation reduces multigenerational sperm miRNA perturbation induced by in utero environmental contaminant exposure

Persistent organic pollutants (POPs) can induce epigenetic changes in the paternal germline. Here, we report that folic acid (FA) supplementation mitigates sperm miRNA profiles transgenerationally following in utero paternal exposure to POPs in a rat model. Pregnant founder dams were exposed to an e...

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Detalhes bibliográficos
Publicado no:Environ Epigenet
Main Authors: Herst, P M, Dalvai, M, Lessard, M, Charest, P L, Navarro, P, Joly-Beauparlant, C, Droit, A, Trasler, J M, Kimmins, S, MacFarlane, A J, Benoit-Biancamano, M-O, Bailey, J L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911352/
https://ncbi.nlm.nih.gov/pubmed/31853372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eep/dvz024
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