PINK1 phosphorylates ubiquitin predominantly in astrocytes

Loss-of-function mutations in PINK1 are causally linked to recessively inherited Parkinson’s disease (PD), with marked loss of dopaminergic neurons in the substantia nigra that are required for normal movement. PINK1 is a nuclear-encoded mitochondrial-targeted kinase that phosphorylates a conserved...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:NPJ Parkinsons Dis
Egile Nagusiak: Barodia, Sandeep K., McMeekin, Laura J., Creed, Rose B., Quinones, Elijah K., Cowell, Rita M., Goldberg, Matthew S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Brief Communication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906478/
https://ncbi.nlm.nih.gov/pubmed/31840043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-019-0101-9
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