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PINK1 phosphorylates ubiquitin predominantly in astrocytes
Loss-of-function mutations in PINK1 are causally linked to recessively inherited Parkinson’s disease (PD), with marked loss of dopaminergic neurons in the substantia nigra that are required for normal movement. PINK1 is a nuclear-encoded mitochondrial-targeted kinase that phosphorylates a conserved...
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| 出版年: | NPJ Parkinsons Dis |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6906478/ https://ncbi.nlm.nih.gov/pubmed/31840043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-019-0101-9 |
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