(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

Mutations in PINK1 and PARKIN cause recessive, early-onset Parkinson’s disease (PD). Together, these two proteins orchestrate a protective mitophagic response that ensures the safe disposal of damaged mitochondria. The kinase PINK1 phosphorylates ubiquitin (Ub) at the conserved residue S65, in addit...

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Publicado no:EMBO Rep
Main Authors: Fiesel, Fabienne C, Ando, Maya, Hudec, Roman, Hill, Anneliese R, Castanedes-Casey, Monica, Caulfield, Thomas R, Moussaud-Lamodière, Elisabeth L, Stankowski, Jeannette N, Bauer, Peter O, Lorenzo-Betancor, Oswaldo, Ferrer, Isidre, Arbelo, José M, Siuda, Joanna, Chen, Li, Dawson, Valina L, Dawson, Ted M, Wszolek, Zbigniew K, Ross, Owen A, Dickson, Dennis W, Springer, Wolfdieter
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576981/
https://ncbi.nlm.nih.gov/pubmed/26162776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201540514
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