The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

BACKGROUND: Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson’s disease (EOPD). Together, the mitochondrial ubiquitin (Ub) kinase PINK1 and the cytosolic E3 Ub ligase PARKIN direct a complex regulated, sequential mitochondrial quality control. Thereby, damag...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Ando, Maya, Fiesel, Fabienne C., Hudec, Roman, Caulfield, Thomas R., Ogaki, Kotaro, Górka-Skoczylas, Paulina, Koziorowski, Dariusz, Friedman, Andrzej, Chen, Li, Dawson, Valina L., Dawson, Ted M., Bu, Guojun, Ross, Owen A., Wszolek, Zbigniew K., Springer, Wolfdieter
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404317/
https://ncbi.nlm.nih.gov/pubmed/28438176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0174-z
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