Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin

Loss-of-function mutations in PINK1 or PARKIN are the most common causes of autosomal recessive Parkinson's disease. Both gene products, the Ser/Thr kinase PINK1 and the E3 Ubiquitin ligase Parkin, functionally cooperate in a mitochondrial quality control pathway. Upon stress, PINK1 activates P...

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Pubblicato in:PLoS Comput Biol
Autori principali: Caulfield, Thomas R., Fiesel, Fabienne C., Moussaud-Lamodière, Elisabeth L., Dourado, Daniel F. A. R., Flores, Samuel C., Springer, Wolfdieter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222639/
https://ncbi.nlm.nih.gov/pubmed/25375667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003935
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