Structural insights into ubiquitin phosphorylation by PINK1

Mutations of PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin (Ub) ligase parkin can cause familial parkinsonism. These two proteins are essential for ubiquitylation of damaged mitochondria and subsequent degradation. PINK1 phosphorylates Ser65 of Ub and the Ub-like (UBL) domain of parkin...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Rep
मुख्य लेखकों: Okatsu, Kei, Sato, Yusuke, Yamano, Koji, Matsuda, Noriyuki, Negishi, Lumi, Takahashi, Akiko, Yamagata, Atsushi, Goto-Ito, Sakurako, Mishima, Masaki, Ito, Yutaka, Oka, Toshihiko, Tanaka, Keiji, Fukai, Shuya
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2018
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039469/
https://ncbi.nlm.nih.gov/pubmed/29991771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28656-8
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