Structural insights into ubiquitin phosphorylation by PINK1

Mutations of PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin (Ub) ligase parkin can cause familial parkinsonism. These two proteins are essential for ubiquitylation of damaged mitochondria and subsequent degradation. PINK1 phosphorylates Ser65 of Ub and the Ub-like (UBL) domain of parkin...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Okatsu, Kei, Sato, Yusuke, Yamano, Koji, Matsuda, Noriyuki, Negishi, Lumi, Takahashi, Akiko, Yamagata, Atsushi, Goto-Ito, Sakurako, Mishima, Masaki, Ito, Yutaka, Oka, Toshihiko, Tanaka, Keiji, Fukai, Shuya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039469/
https://ncbi.nlm.nih.gov/pubmed/29991771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28656-8
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