Structural insights into ubiquitin phosphorylation by PINK1

Mutations of PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin (Ub) ligase parkin can cause familial parkinsonism. These two proteins are essential for ubiquitylation of damaged mitochondria and subsequent degradation. PINK1 phosphorylates Ser65 of Ub and the Ub-like (UBL) domain of parkin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Okatsu, Kei, Sato, Yusuke, Yamano, Koji, Matsuda, Noriyuki, Negishi, Lumi, Takahashi, Akiko, Yamagata, Atsushi, Goto-Ito, Sakurako, Mishima, Masaki, Ito, Yutaka, Oka, Toshihiko, Tanaka, Keiji, Fukai, Shuya
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039469/
https://ncbi.nlm.nih.gov/pubmed/29991771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28656-8
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